I'm a new PAP user - just about one month in now. I'm using a Resmed AirCurve 10 VAuto machine. My initial settings where Min EPAP 8, Max IPAP 20, PS 4, Trigger/Cycle Medium, TiMin, TiMax default settings.
I've liked this machine from day one and, other than occasionally fighting leaks, I've taken to the hosehead lifestyle very quickly. But, there were things that could be improved, so I knew I would do some tweaking once I had enough time on the machine to have a decent sense of what to do.
Once thing I'd noticed is, especially when falling asleep, I could feel a "notch" in my breathing on the transition from IPAP to EPAP. It wasn't severe - I still fell asleep fine, but I decided this was the first thing I would tweak. So I made the following changes:
PS: 3, TiMax 2.5 (was 2.0), Cycle: High
I've got to tell you, the difference in comfort is amazing with just these tiny changes. I fall asleep more quickly and I stay asleep longer, with objectively fewer events during the night.
I'm still fighting occasional leak issues, but I know I'll get those dialed in over time. I want to encourage new users out there to stick with it. Download your data and look at it regularly. Ask questions, learn the terminology, learn the settings on your machine. Make changes - small changes, with days or weeks between changes so you can objectively and subjectively measure the effect that a change has made. Lather, rinse, repeat. Getting your optimal therapy dialed in will take time, but stick with it.