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Clonidine Reduced my AHI
#1
Clonidine Reduced my AHI
Hi Guys,


Last week I increased unintentionally my Clonidine dose and surprisingly, my AHI went down from about 10 to 3-4. Curiously, I tried it few times more and the results were the same. What is even more weird is that mask leaks also  went down significantly…. 
 
Questions:
1.   Are any of you familiar with a similar phenomenon?
2.   Is Clonidine supposed to reduce Obstructive or Central events? (in my case these are the Obstructives).
3.    Known side effects of Clonidine?
4.   Any explanation regarding the reduction of the mask leak?
 
Additional notes:
 
5.   I wrongly told you in a previous thread that it was the Otrivine nose drops that affected my AHI.
6.   I’m using low dose Clodinine for years to treat my blood pressure.
 
Thanks,
Arik
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#2
RE: Clonidine Reduced my AHI
Clonidine can reduce or restrict REM sleep in some.

With REM often comes reduced muscle tone, and with reduced muscle tone comes apneas and mask leaks.
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#3
RE: Clonidine Reduced my AHI
(02-04-2019, 03:25 PM)Dog Slobber Wrote: Clonidine can reduce or restrict REM sleep in some.

With REM often comes reduced muscle tone, and with reduced muscle tone comes apneas and mask leaks.

REM and reduced muscle tone? since when?
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#4
RE: Clonidine Reduced my AHI
(02-05-2019, 07:01 AM)crowtor Wrote:
(02-04-2019, 03:25 PM)Dog Slobber Wrote: Clonidine can reduce or restrict REM sleep in some.

With REM often comes reduced muscle tone, and with reduced muscle tone comes apneas and mask leaks.

REM and reduced muscle tone? since when?

Since always.

https://en.wikipedia.org/wiki/Rapid_eye_movement_sleep


Quote:Rapid eye movement sleep (REM sleepREMS) is a unique phase of sleep in mammals and birds, distinguishable by random/rapid movement of the eyes, accompanied with low muscle tone throughout the body, and the propensity of the sleeper to dream vividly.




https://www.news-medical.net/health/REM-...ivity.aspx


Quote:Rapid eye movement (REM) sleep is marked by movement of the eyes and low muscle tone in the body, in addition to more rapid brain waves, similar to that of an awake individual.



https://www.britannica.com/science/sleep/REM-sleep


Quote:The other hallmark finding in REM sleep physiology is a reduced or nearly absent muscle tone (except for the diaphragm, one of the key muscles for maintaining breathing). Muscle activity in REM sleep may be nearly absent (tonic REM sleep) or may be characterized by brief bursts of activity (phasic REM sleep).
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