I live at about 2500-2800ft and have for 20yrs. My family live in NJ which is barely above sea level. I just spent a week in Minneapolis which is about 800ft.
I got home early this morning, hooked back up the CPAP, and put on the mask. First thing I notice is I have trouble breathing out against the pressure. It was very noticeable. Then I realize that I never experienced that while in Minneapolis. BUT, I slept very poorly, waking up many times (as in about 6 - 10 times) each night which is very unlike me. I woke up with my chest pounding and generally just not feeling well. I wish I had taken my oximeter!
The only other difference is I was using a brand new mask (I use the Breeze and the DME had sent me a new one just prior to me leaving) and had not put on the side straps to the headgear. Not that it really does anything that I am aware of but it is a variable. Might have caused leaks but each time I woke up, the mask was not noticeably leaking. Since the headgear for the Breeze is very rigid, I don't think it would have pushed off the nose and I would not have noticed the pressure as much. But, like I said, it is a variable.
When I visit my brother in NJ, I don't sleep as well there, either, but certainly don't wake up ten or more times each night.
So I was wondering if elevation or possibly location had anything to do with it. I don't see how but the pressure difference was very noticeable. I actually had to take off the mask for a second and readjust to it. That's not something I've had to do in a very long time.
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Breathe deeply and count to zen.