Just looked up Apnimed real quick guess they are also doing phase 1 trials of atomoxetine and trazodone.
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Insomnia and treatment?
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06-17-2022, 05:23 PM
(This post was last modified: 06-17-2022, 05:37 PM by ECM5. Edited 5 times in total.)
Insomnia and treatment?
For those who had insomnia before diagnosis, did starting CPAP help? Are there any sleeping medications that do not worsen apnea? I ran across an article stating Lunesta (I know there is a generic name which I cannot spell - Eszopiclone!) might decrease apnea by raising arousal threshold but it was from 2011 so not sure of current status. What about the drug still in clinical trials (by apnimed I think)? Atomoxetine and oxybutynin?
Just looked up Apnimed real quick guess they are also doing phase 1 trials of atomoxetine and trazodone.
06-18-2022, 12:51 AM
RE: Insomnia and treatment?
For me the CPAP is a great help. I would wake up like clockwork at 3 am from a nightmare and often not be able to get back to sleep. In hindsight it should have been obvious that this was me desaturating, but I sure went through a lot of rationalizations of other causes. I also had trouble initiating sleep, particularly at higher altitudes. On a bad night I would typically get 3 hours of sleep, and I seldom got through the night without 5-6 awakenings.
I was very lucky, as I tolerated the CPAP great from the start. (if you mouth breathe much at all and can tolerate a FF mask, I recommend starting with that rather than a nasal, so you can get a successful experience with the CPAP from the get-go. You can always try and troubleshoot a nasal mask later) And for me everything magically resolved just a day or 2 into using the CPAP. I now sleep like a log for 7-8 hours straight. I have never used meds for insomnia so I cannot speak to their relative merits. But it is my understanding that most “successful” meds worsen desaturations because you will sleep right through them rather than waking up to breathe.
06-19-2022, 01:24 PM
RE: Insomnia and treatment?
For insomnia, some people benefit from CBTi, which stands for cognitive bahavioral therapy for insomnia.
06-19-2022, 01:28 PM
RE: Insomnia and treatment?
Thanks, I am familiar with CBTi and it is definitely worth a try. It's harder to find a provider who specializes in it unfortunately, and long wait for appointments. I do have an app
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06-20-2022, 01:09 PM
RE: Insomnia and treatment?
I was taking Trazodone before pap use and continue to take it now. It works well for me. I sleep better now that I use a pap machine, waking up less often, etc., but I have experimented and I still need the Trazodone for good sleep.
06-20-2022, 01:12 PM
RE: Insomnia and treatment?
How much do you take? That is one of the ones they are putting in a new pill combo with the atomoxetine. I think I have taken either 50 or 100 a couple times and it did not do much but there was also once it really knocked me out and next day sedation so I didn't want to take again.
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