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Interesting Article on Pharmacotherapy Options in the Treatment of Apnea
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grumpycat Offline

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Post: #1
Interesting Article on Pharmacotherapy Options in the Treatment of Apnea
Came across this in my internet meanderings and thought others might be interested. This is an article for US Pharmacist, with citations and basically says that pharmaceuticals have not been shown to provide a significant benefit. The article lists some drugs which make apnea worse.

Well, it looks like the article is too big to include as an attachment. You can google USPharmacist (no space) and then search under sleep apnea, to find the article. The info on drugs which worsen apnea follows:

Medications That May Worsen OSA: CNS depressants such as opiates, benzodiazepines, barbiturates, older sleep agents, and alcohol can actually worsen OSA by adversely affecting the control of ventilation during sleep and making the upper airway more easily collapsible.37,38 They are an additional threat due to their muscle relaxant properties.37 Other medications such as propranolol, a beta-blocker, and sildenafil, an erectile dysfunction medication, can also worsen OSA.38 Therefore, pharmacists should review medication profiles for those patients with OSA since there are few pharmacologic treatments available. Pharmacists should recommend discontinuation of medications that can have a negative impact on the treatment of OSA.


As usual, I make no claim as to the accuracy or correctness of any information provided. Also, INFORMATION ON APNEA BOARD FORUMS OR ON APNEABOARD.COM SHOULD NOT BE CONSIDERED AS MEDICAL ADVICE. ALWAYS SEEK THE ADVICE OF A PHYSICIAN BEFORE SEEKING TREATMENT FOR MEDICAL CONDITIONS, INCLUDING SLEEP APNEA. INFORMATION POSTED ON THE APNEA BOARD WEB SITE AND FORUMS ARE PERSONAL OPINION ONLY AND NOT NECESSARILY A STATEMENT OF FACT.
04-17-2013 06:27 PM
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DocWils Offline

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Post: #2
RE: Interesting Article on Pharmacotherapy Options in the Treatment of Apnea
I think I've mentioned this problem several times in various posts, but yes, many medications are known to affect one's ability to breath comfortably during sleep. Please be sure of any such effects on any medications you may have been prescribed and when possible, avoid taking them before bedtime. If the prescription is timed so that you are supposed to, please take it up with your doctor and pharmacist to be sure that it may not be a type of drug that may cause respiratory resistance, muscle relaxant or other possible effects that could lead to forms of OSA or CSA.
04-17-2013 06:39 PM
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grumpycat Offline

Preferred Members

Posts: 27
Joined: Mar 2013

Machine: resmed S9autoset
Mask Type: Nasal mask
Mask Make & Model: wisp
Humidifier: H5i
CPAP Pressure: 5-20
CPAP Software: ResScan SleepyHead

Other Comments: In his house at R'lyeh, dead Cthulhu waits dreaming.

Sex: Male
Location: new jersey, u.s.a.

Post: #3
RE: Interesting Article on Pharmacotherapy Options in the Treatment of Apnea
BTW, thank you Doc for providing the disclaimer I used at the end of my post. I should have cited you as the source.

Also, thought your response to user Evamarie was exemplary in its depth and kindness.

Best wishes.
04-17-2013 06:45 PM
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DocWils Offline

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Posts: 1,271
Joined: Jul 2012

Machine: Philips Remstar series 60
Mask Type: Nasal pillows
Mask Make & Model: ResMed P10
Humidifier: same as machine
CPAP Pressure: 5-15
CPAP Software: SleepyHead

Other Comments:

Sex: Male
Location: Switzerland

Post: #4
RE: Interesting Article on Pharmacotherapy Options in the Treatment of Apnea
Thanks on both counts.

The disclaimer is not mine, actually, but imposed (and I am perfectly happy about it) from the legal eagles above to prevent any possible repercussions to the Apnoea Board should someone get an itch to sue for any reason. I find it very wise and am fully for it. You may thank our fearless leader for the disclaimer and praise his wisdom. As for citing the source, please take that up with SuperSleeper, as Supes is the source for this, or the legal department at least.

To be honest, I was a bit ticked at Evamarie, because she did not give a proper history in her first mail, which would have saved me from writing a great deal of what I had written, since the causes were from a completely different source than one could infer from the first mail. I hate being imprecise or going down a wrong path in a specific case, and that emphasises the need for the correct information from the get go. And, of course, my time is very limited here, so lengthy replies that don't actually address the question prevents me from helping someone else, or sharing something.

Good lesson to me, a reminder to always get a complete history first. Still, it was good that she felt relieved from the support from our merry band of hose heads. That is what the forum is there for.
(This post was last modified: 04-17-2013 07:49 PM by DocWils.)
04-17-2013 07:48 PM
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