I did get some blisters on my nose bridge. To deal with that, I started using a band aid brand fingers and toes blister gel guard on the bridge of my nose. That is possibly overkill but the gel guard is nice and thick and stays put and is very comfortable. It does use a very strong adhesive. I've been thinking of applying it to clothes once or twice before putting it on to weaken the adhesive a bit so removal is more gentle. I usually just leave it on for a few days and then take it off since it's designed for multi day use.
Lately I've been setting my humidifier to 3 and I use a tight fitting resmed zipper wrap and a loose fitting contour cpap pillow brand hose cover at the same time. I don't know if the double hose cover set up does anything significant but I think it helps a little bit.