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[News] Ibuprofen may help slow the aging process
#1
Is ibuprofen the key to anti-aging?

Study finds painkiller extends life of flies and worms by equivalent of 12 human years

by Heather Saul


Tests on a commonly-used painkiller have revealed the drug significantly extended the lives of worms and flies, sparking hopes it could be the key to anti-aging in humans.

In laboratory tests, ibuprofen was found to extend the lives of yeast, worms and fruit flies by the equivalent of about 12 years in human terms.

Ibuprofen is a nonsteroidal anti-inflammatory drug used to reduce pain, inflammation and help with a temperature. First created in the 1960s, it became available to buy over the counter in the 1980s.

In the study, the drug appeared to have an all-encompassing anti-aging effect, with creatures living longer as well as maintaining their fitness and health as they aged.

Lead researcher Professor Michael Polymenis, from Texas A&M University in the US, said: "We are not sure why this works but it is worth exploring further.

"This study was a proof of principle, to show that common, relatively safe drugs in humans can extend the lifespan of very diverse organisms.

"Therefore, it should be possible to find others like ibuprofen with even better ability to extend lifespan, with the aim of adding healthy years of life in people."

A possible clue to the effect came when the scientists found that ibuprofen interfered with the ability of yeast cells to pick up tryptophan, an amino acid protein building block found in every organism. Tryptophan is an essential nutrient obtained in the diet from protein.

In the new research, scientists exposed the three model organisms to ibuprofen. The doses used were broadly comparable to the doses consumed by humans.

The treatment added about 15 per cent to the lives of the different species, which in human terms amounts to an extra dozen or so years of life.

Both the treated flies and worms appeared healthier in old age than those left untreated.

Co-author Dr Chong He, from the Buck Institute for Age Research in California, US, said: "We have some preliminary data on worms that showed that this drug also extended the health span in worms.

“It made them live not just longer but also more healthy. You can measure the thrashing of the worms. If they’re healthy, they do have a tendency to thrash a lot, and also we can measure the pumping as they swallow, because if they’re healthy, the pumping is faster.

Dr Brian Kennedy, also from Buck, said his institute is primarily interested in identifying why people are more prone to becoming sick as they age.

He said: "We think that by understanding those processes, we can intervene and find ways to extend human health span, keeping people healthier longer and slowing down aging. That's our ultimate goal.

"The research shows that ibuprofen impacts a process not yet implicated in aging, giving us a new way to study and understand the aging process."

Molecular biologist Ellen Nollen, of the University of Groningen in the Netherlands, told Science Mag the study supports further testing on mice. “They convincingly show that ibuprofen prolongs life span in these model organisms,” she said.

The study Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import has been published today in the online journal Public Library of Science Genetics.

Fair use from:
http://www.independent.co.uk/life-style/...35169.html


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#2
That is if it doenst kill your kidneys. My wife is stage 2 kidney disease which is no huge thing at this point but her GP and Kidney specialist put the kabosh on ever taking Ibuprofen or other NSAID again. Tylenol only and that aint great for the liver but she doesnt have liver problems so thats the one she takes as sparingly as possible.
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#3
I find the article in many ways irresponsible - we are very well aware of the damage ibuprofin can do the the human body - it does not and cannot extend human life in the way they imply. Just another in a long line of journalists sensationalizing something they have no understanding of in order to fil column inches, and in the process utterly misinforming the public by implying things that are utterly not supported by the research they are reporting on. Instead, they imply that taking ibuprofin will extend human life, and I will be dealing with more destroyed livers and kidneys in my ER. There is also no clear use to the finding that inhibiting tryptofan extends lives of humans - it would imply, for instance, that vegans would live longer and healthier lives than non vegans, and so far, there is no overwhelming evidence in that direction. We are far longer lived and far more complex than the models they used, and what applies to yeast or a fruit fly does not always apply when scaled up to humans. Often the opposite.

Humans are huge compared to yeast of fruit flies - in order to ingest anything in amounts that would have an effect on us as described in the paper, we would have to ingest rapidly toxic amounts of ibuprofin, given the relative dosages in the actual paper, scaled up for humans. (yes, I get these papers for free - I can look them up quickly on the office computer).
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#4
Ibuprofen imo should be made illegal
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#5
Just what we need: Worms and flies that live longer.

Ibuprofen has its uses. But, it probably should have been kept by prescription only.
The FDA and Drug companies have an incestuous relationship., So, big pharma gets its wishes.

Seems upside down to criminalize Ibuprofen when the US is legalizing pot.
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#6
When I was in the AF, ibuprofen was known as Vitamin M. I used to be if you were taking it, you weren't supposed to be flying. Now, you can self-medicate if the total dose is 400 mg or less. When I tore up my ankle, the flight doc wrote me a script for 800 mg but put it in my wife's name and told me not to take it 8 hours before flying.

I do take 800 mg twice a day to curb some of the inflammation in my back and I also have regular blood work because of one of the other drugs I am on. My wife can't take it due to some of the pain killers she is on.

And if we want something to extend the life of worms, try tequila - unless the worm drowns. Laugh-a-lot

Homer
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