Hello Guest, Welcome to Apnea Board !
As a guest, you are limited to certain areas of the board and there are some features you can't use.
To post a message, you must create a free account using a valid email address.

or Create an Account


New Posts   Today's Posts

[News] UIC study: Can drug used for nausea in chemotherapy relieve sleep apnea
#1
No drug treatments exist to treat sleep apnea, a disorder that affects more than 18 million Americans, but researchers at the University of Illinois at Chicago College of Nursing are working to change that.

A research team led by David Carley, director of the UIC Center for Narcolepsy, Sleep and Health Research, has received a $5 million three-year federal grant to find out if a cannabinoid drug can reduce sleep apnea and protect against diseases linked to it, according to a release from UIC.

The grant, the single largest research award ever received by the UIC College of Nursing, is from the National Heart, Lung and Blood Institute, one of the National Institutes of Health. Known as the Pharmacotherapy of Apnea by Cannabimimetic Enhancement, or PACE trial, it is the first NIH-sponsored multi-site drug trial for obstructive sleep apnea, the release said.

“Sleep-related breathing disorders, especially obstructive sleep apnea, pose significant health problems,” Carley, who is professor of biobehavioral health science at UIC, said. “Individuals suffering from sleep apnea have an increased risk for coronary heart disease, stroke, high blood pressure and type 2 diabetes.”

Obstructive sleep apnea is a disorder where breathing is briefly but repeatedly interrupted during sleep. It occurs when the throat muscles fail to keep the airway open during sleep, despite efforts to breathe.

The most common current treatment for sleep apnea is CPAP, or continuous positive airway pressure, in which a machine delivers air through a tightly sealed mask over the nose.

Researchers have attempted to identify drugs to treat sleep apnea for at least 30 years, Carley said.

“By providing a path toward the first viable obstructive sleep apnea drug, our studies could have a tremendous impact on clinical practice,” he said.

One project in his two-part study will be a trial of dronabinol, a cannabinoid drug currently marketed under the trade name Marinol, used to treat nausea and vomiting in chemotherapy patients. It is also prescribed to treat loss of weight and appetite in people who have AIDS.

Patients will be divided into three groups. One group will be given a low dose of the drug, the second group will get a higher dose, and the third, a placebo. Participants will receive the drug once daily before bed for six weeks.

Researchers will measure the drug’s effectiveness by the number of apnea episodes per hour of sleep -- the standard clinical measure of sleep apnea severity. Normal is fewer than five episodes per hour; mild is five to 14; moderate is 15 to 30; and severe is more than 30.

Researchers will also measure blood oxygenation, sleep quality, blood pressure control and daytime alertness, Carley said.

In a second project, UIC researchers will undertake a basic neuroscience study in animal models to define the mechanism of action of dronabinol.



Carley’s collaborators are from the UIC departments of pharmacology, medicine, and epidemiology and biostatistics, and from Northwestern University’s neurology department.
Post Reply Post Reply
#2
I welcome every bit of research in the field. Who knows, something good may come of it.
Post Reply Post Reply


Possibly Related Threads...
Thread Author Replies Views Last Post
  New to Board not to Sleep Apnea Dr Bobs Patient 6 334 Yesterday, 12:18 AM
Last Post: DrmWEaver
Sad [CPAP] My Sleep Apnea Story and CPAP Issue ihatesleepapnea2017 8 215 03-17-2017, 07:14 PM
Last Post: trish6hundred
  No sleep study but buying an auto cpap machine today mikeinthecountry344 6 372 03-16-2017, 07:25 PM
Last Post: trish6hundred
  [Diagnosis] Had at home sleep study done not sure about results Bobbyjones 27 1,003 03-15-2017, 09:43 AM
Last Post: Sleeprider
  Introduction - Newly Diagnosed with Sleep Apnea insignia100 20 528 03-13-2017, 11:49 AM
Last Post: Melman
  Can you have sleep apnea during the day? zonk 21 49,706 03-13-2017, 12:20 AM
Last Post: Lkng67
  Alarmingly High AHIs from sleep study 98taco3 11 818 03-09-2017, 06:58 PM
Last Post: rafairchild2

Forum Jump:

New Posts   Today's Posts




About Apnea Board

Apnea Board is an educational web site designed to empower Sleep Apnea patients.

For any more information, please use our contact form.