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No reduction in heart attacks for cpap users
#11
I found this statement particularly interesting:

Quote:The National Health and Medical Research
Council of Australia and Philips Respironics
provided the main funding for the trial. In-kind
donations were provided by Respironics for the
CPAP equipment and by ResMed for the sleep
apnea diagnostic devices. None of the funding
agencies contributed to the design of the trial,
the collection or analysis of the data, the writing
of the manuscript, or the decision to submit the
manuscript for publication.

I'm waiting for the equipment donators to provide their responses to the article.



Warning: Eating chocolate may cause your clothes to shrink!
[Image: ry6XtE9.gif] <---- That's ME!
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#12
New England Journal of Medicine should not have published this "study". The original hypothesis is that inadequate therapy would show a reduction in cardiovascular events. Their results confirmed that inadequate therapy is inadequate therapy. Nothing new here.

Rich
Apnea Board Member RobySue has posted a Beginners Guide to Sleepyhead Software here:  http://www.apneaboard.com/wiki/index.php...SleepyHead

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#13
(08-28-2016, 08:07 AM)cate1898 Wrote: After reading that article, I'd like to know who funded this study.

Supported by project grants (1006501 [2011–2015] and 1060078 [2014–2016]) from the National Health and Medical Research Council (NHMRC) of Australia and by Respironics Sleep and Respiratory Research Foundation and Philips Respironics. Supplementary trial funding was provided by Fisher & Paykel Healthcare, the Australasian Sleep Trials Network (enabling grant 343020 from the NHMRC), the Spanish Respiratory Society (grant 105-2011 to Drs. Barbe and Mediano), and Fondo de Investigaciones Sanitarias (grant 13/02053 to Drs. Barbe and Mediano). In-kind donations were provided by Respironics for CPAP equipment and by ResMed for sleep apnea diagnostic devices.
DeepBreathing
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Bed

INFORMATION ON APNEA BOARD FORUMS OR ON APNEABOARD.COM SHOULD NOT BE CONSIDERED AS MEDICAL ADVICE. ALWAYS SEEK THE ADVICE OF A PHYSICIAN BEFORE SEEKING TREATMENT FOR MEDICAL CONDITIONS, INCLUDING SLEEP APNEA. INFORMATION POSTED ON THE APNEA BOARD WEB SITE AND FORUMS ARE PERSONAL OPINION ONLY AND NOT NECESSARILY A STATEMENT OF FACT.
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#14
(08-28-2016, 08:07 AM)cate1898 Wrote: After reading that article, I'd like to know who funded this study.
http://www.nejm.org/doi/suppl/10.1056/NE...osures.pdf

INFORMATION ON APNEA BOARD FORUMS OR ON APNEABOARD.COM SHOULD NOT BE CONSIDERED AS MEDICAL ADVICE. ALWAYS SEEK THE ADVICE OF A PHYSICIAN BEFORE SEEKING TREATMENT FOR MEDICAL CONDITIONS, INCLUDING SLEEP APNEA. INFORMATION POSTED ON THE APNEA BOARD WEB SITE AND FORUMS ARE PERSONAL OPINION ONLY AND NOT NECESSARILY A STATEMENT OF FACT.
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#15
AHI 3.7 + of 3.3 hr = not well controlled and failure
Mine, AHI below 1 + 8 hours = well controlled and success

My cardiologist told me, recent studies shows sleep apnea linked to cancer
not breathing while you're sleeping is a no laughing matter


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#16
What a bunch of baloney. Take someone with clogged pipes, put them on a sub optimal ressure, on a straight cpap, for a few hrs a night, bad AHI.numbers and then declare cpap doesnt help when they croak.

Lets try this just using my numbers.
Lets take a healthy, 6ft 3 in doc out of this group of brainiacs.
Strangle him at night to a AHI of 17 and drop his O2 levels to 63% during the strangling.
Now when our strapping bull of a doc has a heart attack which he will in few yrs, lets tell him nah no use for you to go on the hose. It wont help ya.
See how long before he has the "big one" and goes to join Elisibeth.

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#17
As someone up-thread predicted, this has made the news in all its abbreviated stupidity. In my case, the CBC.
So I sent them a stiffly worded tweet.
BTW, there was a related editorial in the same issue which pointed out the problems with the study. Of course, who reads those?
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#18
Most members of the media have no idea about how statistics work nor how to interpret a study, flawed or otherwise. Which leads to many stories like "Bacon Kills!" and "Bacon Good For You".

For the record, I am in the camp of "Everything is Better With Bacon, Including Bacon"
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#19
Pardon me for my skepticism, but large statistical studies of this type tend to confuse correlation with causation and are somewhat flawed by patients with significant co-morbidities. One might suspect that the controls for making such a sweeping assessment of risk may have been inadequate to the task.

"Participants who then consented to continue into the study's main phase, were randomly allocated (like the toss of a coin) to either receive treatment with CPAP, or to continue with usual medical care. In this main phase, the effects of CPAP on cardiovascular disease will be evaluated." One might assume that continuing with the "usual medical care" involved interventional drugs that might have skewed the results.

This is the study where the conclusion should be prefaced with: "It generally appears that within this specific cohort, these findings seem statistically relevant, but may not be generalized to apply to individual patients or extended to a more global population.

From the New England Journal of Medicine ...

"Obstructive sleep apnea causes episodic hypoxemia and nocturnal sympathetic nervous system activation and elevates blood pressure and markers of oxidative stress, inflammation, and hypercoagulation. Large negative intrathoracic pressure swings also impose mechanical stress on the heart and great vessels. Population-based and sleep-clinic–based cohort studies have shown an association between obstructive sleep apnea and cardiovascular events, particularly stroke. Randomized, controlled trials have shown that treatment with continuous positive airway pressure (CPAP) lowers systolic blood pressure by 2 to 3 mm Hg in patients with normotensive obstructive sleep apnea18 and by 6 to 7 mm Hg in patients with resistant hypertension, improves endothelial function, and increases insulin sensitivity. Observational clinical studies have shown that the use of CPAP is associated with lower rates of cardiovascular complications and of death from cardiovascular causes, especially among patients who are adherent to treatment."

"Obstructive sleep apnea is a common condition among patients with cardiovascular disease, affecting 40 to 60% of such patients. Because the risks of recurrent cardiovascular events among these patients remain high despite contemporary therapies, CPAP could be a useful additional treatment for the prevention of these events. We describe the main results of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a secondary prevention trial that was designed to evaluate the effectiveness of CPAP in reducing the rate of cardiovascular events among patients with obstructive sleep apnea."

"A primary end-point event was confirmed in 436 participants — 229 (17.0%) in the CPAP group and 207 (15.4%) in the usual-care group (hazard ratio with CPAP, 1.10; 95% confidence interval [CI], 0.91 to 1.32; P=0.34)"

Say what?

"Participants in the SAVE study who were assigned to CPAP adhered to the treatment for a mean of 3.3 hours per night over several years, which is similar to the mean adherence in other reports of CPAP use in patients who had no or minimal daytime sleepiness and which is consistent with CPAP use in clinical practice.

However, although this overall level of adherence to CPAP therapy exceeded the estimates in our power calculations, it may still have been insufficient to provide the level of effect on cardiovascular outcomes that had been hypothesized.

For practical reasons and to ensure efficient recruitment and consistency of data across multiple sites, we used a simple screening device (ApneaLink) that was based on oximetry and nasal pressure recordings and used automated algorithms to analyze signals, rather than the conventional standard test for obstructive sleep apnea in which polysomnographic data from an overnight stay in a hospital or clinic are scored manually."

http://www.nejm.org/doi/full/10.1056/NEJ...#t=article

Sorry to say, I find the difference between the two groups 229 vs. 207 to be statistically irrelevant to me although you can compute statistical values from any sample. Just reading through the methodology made me question the assertiveness of the statement that was released to the media. But, then again, nobody ever said the headline had to be supported by the body text.

I suggest you read the study for yourself and draw your own conclusions. Mine were "ho hum" let's get funding for the next study.




"Participants will then be followed up by hospital staff for 2-7 years until the end of 2015, and their health and the impact of the OSA treatment will be evaluated." Were these clinical evaluations against baselines, were they simply self-administered, or guided questionnaires that concentrated on events?"

"The object in life is not to be on the side of the majority, but to escape finding oneself in the ranks of the insane." -- Marcus Aurelius
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#20
(08-29-2016, 12:47 AM)srlevine1 Wrote: I suggest you read the study for yourself and draw your own conclusions. Mine were "ho hum" let's get funding for the next study.

The "conclusion" should read "non-compliant use of CPAP is no different than non use of CPAP among cardiac patients."

Non compliance is a major problem for Apnea sufferers and those paying for their therapy. Insurance companies and Medicare do what they can to force compliance during the first few months of therapy but lose control in the long run. This study should or could be used to encourage CPAP users to use their machines all night every night. To put this perspective I could get an average compliance of 3.3 hours per night by using my machine for 3 nights per week.

Rich
Apnea Board Member RobySue has posted a Beginners Guide to Sleepyhead Software here:  http://www.apneaboard.com/wiki/index.php...SleepyHead

Download Sleepyhead
Organize your Sleepyhead Charts
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