Getting back to the original question about the cluster of centrals - I used to get that too when I used an Autoset. Always between 04:30 and 06:00. Changing to an AVS machine eliminated them completely (along with almost all other centrals and all obstructive apneas). Big extra cost, but for me it was worth every penny.
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ME50 i'm pretty sure I had a defective SD card. Even that data was not readable. I could see the data files in the directory. I think the little lock/unlock button stuck out too far and was hanging going in and out.
Last night I put a new SD card in my Autoset. It read the card without error and now today the card goes in and out smoother and my data is accessible without issues in both SH and Rescan. Every thing looks good today. No cluster of CAs, so I figure that was just a fluke. Now I will maybe be able to better analyze data when things look unusual.