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Scientific data analysis auto vs fixed
#1
What are your thoughts on this news article?

https://www.pulmonologyadvisor.com/obstr...le/766757/
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#2
The Chest paper itself, other than the abstract, is behind a paywall as usual (US$36 in this case). Foo.

The main objection I have is that we're not told (presumably this is in the paper) what APAP ranges were used. Was every patient in that group blindly given the old 4-20 treatment, or what?
"I wanted to be a Boy Scout, but I had all the wrong qualities.  They were looking for kids who were trustworthy, loyal, helpful, friendly, courteous, kind, obedient, cheerful, thrifty, brave, clean, and reverent.  Whereas I tended to be devious, fickle, obstructive, hostile, rude, mean, defiant, glum, extravagant, cowardly, dirty, and sacrilegious."  (George Carlin)
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#3
There are on going studies following this. Here's one: https://clinicaltrials.gov/ct2/show/NCT03319888

For now I won't draw any conclusions.
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#4
This very short article is a summary of an abstract of an article that compares the change in estimated glomerular filtration rate (eGFR) (kidney function) in three groups - untreated OSA, treated with CPAP, and treated with APAP. This summary does not quantify the differences, but merely says that treatment with CPAP was (or may be) 'slightly' better.

This is the first article I have seen examining the relationship between sleep apnea and kidney failure; their may be other studies, considering how many people in the US and Canada are on dialysis.

Without the numerical data to support the claims, I am not persuaded to change my treatment for either ailment.

The full article is available through https://journal.chestnet.org/article/S00...0634-2/pdf for $36 USD where you can read the full abstract for free.
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#5
That is a fairly good sized population, but I agree that I would like to know what sorts of settings were used for APAP. Creatinine levels are an issue for diabetes so it could make a big change in recommendations. The problem with the follow up study that Walla Walla indicated is that they are not including APAP and they have fewer participants.
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