Hello Guest, Welcome to Apnea Board !
As a guest, you are limited to certain areas of the board and there are some features you can't use.
To post a message, you must create a free account using a valid email address.

or Create an Account

New Posts   Today's Posts

Something to Grapple with: How Wily Lyme Disease Prowls the Body
Something to Grapple with: How Wily Lyme Disease Prowls the Body

The sneaky germ uses a mechanism like that of white blood cells to reach vulnerable tissues and hide from antibiotics

By Knvul Sheikh on August 25, 2016

See the full article here: http://www.scientificamerican.com/articl...-the-body/#

Lyme disease is an incredibly evasive adversary. No one is entirely sure how the bacterium that causes it spreads so widely throughout the body or why symptoms sometimes persist after the infection has been treated with antibiotics. Now researchers at the University of Toronto may finally have an explanation: The tiny, spiral-shaped bacterium called Borreliaburgdorferi can quickly grapple along the inner surfaces of blood vessels to get to vulnerable tissues or to hiding places where it can hole up beyond the reach of drugs.

B. burgdorferi uses a special adhesive protein on its surface to grab like a hook onto the endothelial cells that line blood vessels, attaching and detaching rapidly as it migrates to its destination, the Toronto microbiologists explain in a new study published Thursday in Cell Reports. “This mechanism is how the bacteria can overcome the fast flow of blood and avoid getting swept away,” says lead author Rhodaba Ebady. It is also likely that this tactic helps the pathogens get to sites where they are able to evade the immune system and treatment, Ebady says.

Note: using the link above; on the right of the page there are several other articles pertaining to Lymes I'm not going to repost here.
Warning: Eating chocolate may cause your clothes to shrink!
[Image: ry6XtE9.gif] <---- That's ME!
Post Reply Post Reply

Donate to Apnea Board  
Thanks For your links, you do good work.

One of the conditions I have is Lyme disease. Two years of treatment (antibiotics) and forgetting about it most of the time. I have Unilateral diaphragmatic paralysis (Right side) that could be caused by the Lyme disease that is an incredibly evasive adversary. No one is entirely sure how the bacterium that causes it spreads so widely throughout the body or why symptoms sometimes persist after the infection has been treated with antibiotics.

The paper you link to I will take to my doctor. Can I say Thanks too many times.

Post Reply Post Reply
I mentioned before, I contracted Lyme's in 2013. With symptoms of fever, headache and fatigue, I went to an urgent care center who diagnosed a urinary tract infection, and sent me home to take Cipro (antibiotic). The Cipro did beat back the Lymes, enough for me to return to work, but shortly afterward, I woke with numbness on one side of my face. I was referred for a CT scan which was negative for stroke or other physical abnormality, and released. I completed the course of Cipro. A few weeks later, we were moving into our new home, and I was so fatigued, I could not lift boxes. The first night after moving in, I woke with tingling in my fingers, double vision and headache.

We went to the emergency room, and I was admitted for diagnostics. That first night in the hospital, I was in pain, and had not pain reliever, and I slept fitfully. In the morning I awoke to find half my face was paralyzed (Bell's Palsy). I was seeing neurologists, pulmonologists, opthamologists, interists, infectious disease specialists, and they would all meet in the morning and talk about my "interesting" case. By the second day, I had bilateral facial paralysis and could no longer chew food, talk, and swallowing was getting difficult. Endless blood tests, CT scans, MRI and doppler ultrasounds, did not reveal anything. On the third day, it was concluded I had some kind of infection, and was placed in isolation. Among many other tests, a lumbar puncture was performed. Finally on the 4th day, the doctor walks in and announces, "the good news is, you don't have AIDS, Gonorrhea or syphalis". I'm certain my wife and mother in law were impressed. They found the Lyme's infection in the spinal fluid. By this time, I required a a walker, wore an eye patch for the double vision, and was in pretty bad shape.

I started intravenous antibiotics in the hospital, was fitted with a PICC line and sent home for over a month of antibiotic therapy. I didn't return to work for another two months and when I did, I was still weak and suffering cognitive issues. I was fired for performance the next month, shortly after my 1-year anniversary at that job. I was never employed again, and lived off substantial savings we had accumulated until I retired last December. It seemed I should have gotten disability, but how do you claim for something you can't see. I'm generally healthy, have my strength back with less endurance, but Lymes ended my career and changed my life.

Lyme's sucks, and you never know how it will affect you, or how it might resurface years after the infection is gone. Relavent to this discussion, my Lymes did not show up in the blood tests, and was not diagnosed until it was found in the cerebro-spinal fluid.
Post Reply Post Reply
It's a terrible illness & I really feel for those with it & have copped the run around, both medically & financially.  It sure can wreck someone's future.
Here in Oz, our govt will not recognise we have it (tho many have been diagnosed via tests done in USA).  Govt will not allow any doc to treat it legally.  Recently various borrelia have been found in ticks on different native animals.  An online organisation has arisen to support those with it and push the case for it's recognition.  http://www.lymedisease.org.au/

It has me utterly flummoxed how an illness is not recognised in a country & therefore patients are not treated, but thanks to the Lyme Disease Association we are getting close.
Post Reply Post Reply
To the best my memory works, I think Lyme's disease was part of one of my blood tests about 2 years ago. I have to guess some of my various symptoms could resemble it, but Lyme's was crossed off after testing.

Even a 1,000 mile trip requires a first step. My recommended first steps are getting good shoes and 2 cups o coffee

Wiki Info for Beginners
Sleepyhead Chart Organization
Post Reply Post Reply

Donate to Apnea Board  
Sadly, even the best Lyme tests yield 50% false negatives. This is one reason Lyme is supposed to be a clinical diagnosis.

SleepRider - I've been on a similar journey, but it started for me when I was a teen.

Mrsmagoo - It's heartbreaking and devastating how governments and organizations have turned their backs on sick people. The Lyme epidemic is much like the AIDS epidemic; AIDS patients have paved the way, and Lyme patients have only just begun on the path (or trying to get recognized and treated).
Post Reply Post Reply
My late neighbor developed lyme disease in the 80s. Took them some years to even diagnose it. Long term antibiotics improved her condition, but didn't resolve it. However, she'd been bedridden before antibiotics, and then she could walk. She actually went on a couple of foreign vacations after her semi-recovery. Died from cancer, so unrelated to all the complications of Lyme.
Post Reply Post Reply
(03-07-2018, 10:05 PM)Mosquitobait Wrote: My late neighbor developed lyme disease in the 80s. ... Died from cancer, so unrelated to all the complications of Lyme.

Lyme is known to cause cancer.

So sorry about your neighbor.
Post Reply Post Reply
Hydrangea - it's ironic you saying the govts turned their backs on lyme, AIDS etc., expecially when it's been proved that AIDS was a science created disease in the Belgian Congo.  We're all sheep & victims I'm afraid, of the very people who we elect to run our national & international affairs.
Post Reply Post Reply

Donate to Apnea Board  

Possibly Related Threads...
Thread Author Replies Views Last Post
  Do statins really reduce your risk of heart disease? zonk 37 9,338 06-16-2015, 10:56 AM
Last Post: Mark Douglas

Forum Jump:

New Posts   Today's Posts

About Apnea Board

Apnea Board is an educational web site designed to empower Sleep Apnea patients.