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Something to Grapple with: How Wily Lyme Disease Prowls the Body
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icyura10 Offline

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Something to Grapple with: How Wily Lyme Disease Prowls the Body
Something to Grapple with: How Wily Lyme Disease Prowls the Body

The sneaky germ uses a mechanism like that of white blood cells to reach vulnerable tissues and hide from antibiotics

By Knvul Sheikh on August 25, 2016

See the full article here: http://www.scientificamerican.com/articl...the-body/#

Lyme disease is an incredibly evasive adversary. No one is entirely sure how the bacterium that causes it spreads so widely throughout the body or why symptoms sometimes persist after the infection has been treated with antibiotics. Now researchers at the University of Toronto may finally have an explanation: The tiny, spiral-shaped bacterium called Borreliaburgdorferi can quickly grapple along the inner surfaces of blood vessels to get to vulnerable tissues or to hiding places where it can hole up beyond the reach of drugs.

B. burgdorferi uses a special adhesive protein on its surface to grab like a hook onto the endothelial cells that line blood vessels, attaching and detaching rapidly as it migrates to its destination, the Toronto microbiologists explain in a new study published Thursday in Cell Reports. “This mechanism is how the bacteria can overcome the fast flow of blood and avoid getting swept away,” says lead author Rhodaba Ebady. It is also likely that this tactic helps the pathogens get to sites where they are able to evade the immune system and treatment, Ebady says.

Note: using the link above; on the right of the page there are several other articles pertaining to Lymes I'm not going to repost here.

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08-25-2016 05:49 PM
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kwhenrykerr Offline
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RE: Something to Grapple with: How Wily Lyme Disease Prowls the Body
Thanks For your links, you do good work.

One of the conditions I have is Lyme disease. Two years of treatment (antibiotics) and forgetting about it most of the time. I have Unilateral diaphragmatic paralysis (Right side) that could be caused by the Lyme disease that is an incredibly evasive adversary. No one is entirely sure how the bacterium that causes it spreads so widely throughout the body or why symptoms sometimes persist after the infection has been treated with antibiotics.

The paper you link to I will take to my doctor. Can I say Thanks too many times.

Just my personal opinion. My posts are not medical advice or a statement of fact. Please consult a qualified physician or other qualified medical personnel. Please comply with all applicable laws, codes, regulations, and protocols.
08-26-2016 04:44 AM
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Sleeprider Offline
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RE: Something to Grapple with: How Wily Lyme Disease Prowls the Body
I mentioned before, I contracted Lyme's in 2013. With symptoms of fever, headache and fatigue, I went to an urgent care center who diagnosed a urinary tract infection, and sent me home to take Cipro (antibiotic). The Cipro did beat back the Lymes, enough for me to return to work, but shortly afterward, I woke with numbness on one side of my face. I was referred for a CT scan which was negative for stroke or other physical abnormality, and released. I completed the course of Cipro. A few weeks later, we were moving into our new home, and I was so fatigued, I could not lift boxes. The first night after moving in, I woke with tingling in my fingers, double vision and headache.

We went to the emergency room, and I was admitted for diagnostics. That first night in the hospital, I was in pain, and had not pain reliever, and I slept fitfully. In the morning I awoke to find half my face was paralyzed (Bell's Palsy). I was seeing neurologists, pulmonologists, opthamologists, interists, infectious disease specialists, and they would all meet in the morning and talk about my "interesting" case. By the second day, I had bilateral facial paralysis and could no longer chew food, talk, and swallowing was getting difficult. Endless blood tests, CT scans, MRI and doppler ultrasounds, did not reveal anything. On the third day, it was concluded I had some kind of infection, and was placed in isolation. Among many other tests, a lumbar puncture was performed. Finally on the 4th day, the doctor walks in and announces, "the good news is, you don't have AIDS, Gonorrhea or syphalis". I'm certain my wife and mother in law were impressed. They found the Lyme's infection in the spinal fluid. By this time, I required a a walker, wore an eye patch for the double vision, and was in pretty bad shape.

I started intravenous antibiotics in the hospital, was fitted with a PICC line and sent home for over a month of antibiotic therapy. I didn't return to work for another two months and when I did, I was still weak and suffering cognitive issues. I was fired for performance the next month, shortly after my 1-year anniversary at that job. I was never employed again, and lived off substantial savings we had accumulated until I retired last December. It seemed I should have gotten disability, but how do you claim for something you can't see. I'm generally healthy, have my strength back with less endurance, but Lymes ended my career and changed my life.

Lyme's sucks, and you never know how it will affect you, or how it might resurface years after the infection is gone. Relavent to this discussion, my Lymes did not show up in the blood tests, and was not diagnosed until it was found in the cerebro-spinal fluid.

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(This post was last modified: 08-26-2016 07:35 AM by Sleeprider.)
08-26-2016 07:34 AM
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