[Treatment] Drug Reaction ?

[kwhenrykerr]

Drug Reaction ?

I started a new drug and my Sleepyhead reports showed an abrupt change. AHI increased and Pressure went to max output. I looked at the charts and did not make any changes to see if it was only temporary. After several weeks of no change I contacted the doctor to report what had happened.

The doctor responded that is was not the drug but to inform my other doctors. This I did. After another two weeks with no good answers I changed my cpap pressure min to see if that would help.

With the higher starting pressure I thought the machine might be able to respond better. This change did not improve my charts any. Another week went by with my cpap now working at it’s max output most of the time.

I stopped the drug and after several days started to see my charts looking like they were before the new drug was added. My charts are still not as good as before but improving.

I am waiting to see the doctors and ask if they will try something else. So far all I am getting is blank faces looking back at me. I am disappointed in that they do not want to look at the Sleepyhead charts.

Has anyone else had a reaction to a new drug and if so can you answer some questions please.


1) What was the drug ?
2) What was the reaction you had ?
3) What did the doctor say and do ?
4) What was the outcome ? Did you change or quit the drug ?


Thank You for responding, my your information help others.

[kwhenrykerr]

My Drug was LISINOPRIL

[OpalRose]

I take the same drug with no problems.

My doctor told me to take it before bed, and I noticed that my AHI would be higher, usually
CA events. I went from a normal for me reading of .5 to 1.5 to between 2 and 3.

I switched back to taking my meds in the morning, and AHI went back to normal.

[silversnore]

I take mine an hour before bedtime, no problems AHI under 1. I however have been taking it longer than I have been on vpap, perhaps acclimated to the effects.

[TASmart]

Are your increased AHI components due to CA? If so max pressure not a good idea. But the CA if caused by the medication may not be treatable with APAP - got any sleepyhead charts for us to look at?

[quiescence at last]

It is possible that the dose of lisinopril may also be in question. I take what is considered minimum except for extreme heart cases, where the minimum is half. my dose is 10 mg, dosing up to 40 mg is common, where anything over 40 has less and less effect. I take mine about dinner time, usually 4 to 6 hours before bed. I have found no effect since I started.

QAL

[CB91710]

I can't take Lisinopril, and it's unfortunate because it is one of the most effective drugs at controlling my HBP.
I am currently taking Valsatran and Amlodipine in combination and the HBP is pretty well controlled.

Lisinopril (and other ACE Inhibitors) works by dilating the capillaries in the lungs and kidneys. This has the effect of immediately reducing blood pressure, but one side effect that is EXTREMELY underreported is a nasty cough. WebMD reports 10%, but comments online, and my doctor's reaction when I reported it lead me to believe that it is far more common.
It comes on slowly... for me I can tolerate the drug for about 2 weeks, then the coughing gets to be so severe that people at work ask if I'm sick, and often times it will get to the point that I am afraid I am going to injure myself.
Enalarpril has the same effect (but is not nearly as effective in controlling HBP)

When I stop taking them, it can take 2-3 weeks for the coughing to go away, that may explain why your AHI did not show a complete improvement after only a few days.

Given the above, it would not surprise me if the drug also has an impact on O2 levels and apnea... but it is obviously the drug that is causing this condition because of the changes coinciding with use.

[ajack]

I can't take an ace inhibitor, there are others

[PaulaO2]

I take a lot of medication and most of it I take in the morning.

Vicodin/Norco (PRN) can sometimes cause higher CA events if I take it several times in a row in the same day. The CI never goes over 5 though.
Baclofen (low oral dose) - my AHI has seemed to lower slowly since stopping this med last month. I didn't realize it had raised it but it would explain a few things.

[kwhenrykerr]

[attachment=3561][attachment=3562]

Here are two Sleepyhead charts. One before starting the new drug and one after. I took the pill before bedtime. The chart is from that first night with the new drug. The following couple of weeks were the same. The months before were stable and the best I had in years. With the fine tuning information written by the many good folks at this forum.




I am going to take the advice and try taking the drug in the morning. Thanks All. I will follow up with a report on what happens.