File:Alternative-approaches-to-treatment-of-Central-Sleep-Apnea-2014.pdf

Divergent approaches to treatment of hypocapnic central sleep apnea syndromes reflect the difficulties in taming a hyperactive respiratory chemoreflex.

sedatives CO2-based stabilization Adaptive ventilation enhanced expiratory rebreathing space (EERS) CO2 manipulation Carbonic anhydrase inhibition Provent and Winx oral appliance Novel pharmacological approaches

In complex apnea patients, single mode therapy is not always successful, and multi-modality therapy might need to be considered. Phenotyping of sleep apnea beyond conventional scoring approaches is the key to optimal management.